Ddit4 hif1a
Clinical interest in DDIT4 is based primarily on its effect on mTOR, which has been associated with aging and linked with diseases such as tuberous sclerosis, lymphangioleiomyomatosis, diabetes, and cancer. In particular, the overactivation of mTOR in many cancer types has led to the development of mTOR inhibitors for cancer treatment. DDIT4 has begun to receive attention in this regard via the diabetes drug Metformin which has been shown to reduce cancer risk and incr… WebMar 28, 2024 · 通过在ddit4启动子结构中引入一系列缺失，作者发现了序列中一段相对保守的缺氧诱导因子（hif）结合基序，并进一步通过对肝裂解产物以及人原代肝细胞的免疫 …
Ddit4 hif1a
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WebNov 23, 2016 · Further we demonstrated that DDIT4 exert these effects down-stream to HIF1α. Our findings provide an insight in regulation of adult stem cells homeostasis by … WebMar 17, 2024 · Current research supported oxygen sensing is a complex signal network, and the study of hypoxia-related protein DDIT4 was a potential visitor in the oxygen sensing …
WebMar 2, 2024 · Analysis of genetic screen data reveals that, in normoxia, HIF1A behaves as a strong tumor suppressor, which is genetically linked to its target DDIT4, a repressor of … WebXiaoyu Deng is an academic researcher from Zhengzhou University. The author has contributed to research in topic(s): Nasopharyngeal carcinoma & DDIT4. The author has co-authored 2 publication(s).
WebInhibition of mTORC1 is mediated by a pathway that involves DDIT4/REDD1, AKT1, the TSC1-TSC2 complex and the GTPase RHEB. Plays an important role in responses to … WebFeb 10, 2024 · In contrast, sgRNAs directed against multiple genes, including Hif1a, Ddit4 (a HIF-1α downstream target), and Ptger2 (encoding prostaglandin receptor E2) were increased in abundance in pre-Tfh ...
WebFeb 21, 2024 · Furthermore, we provide evidence that HIF-3α2 is also expressed in seven other primary endothelial cell types, suggesting that this may be a common feature of HIF-3α2 in endothelial cells. Keywords: DDIT4; HIF3A; …
WebFeb 24, 2024 · REDD-1 Antibody (A-4) is an IgG 1 κ mouse monoclonal REDD-1 antibody (also designated DNA Damage Inducible Transcript 4 antibody, REDD1 antibody, Protein … flo services incWebMar 1, 2024 · Oxygen depletion (i.e., hypoxia) results in the rapid stabilization of HIF1α and allows the HIF1 heterodimer to induce genes involved in glucose uptake, glycolysis, and angiogenesis to adapt to hypoxia and decrease mitochondrial respiration ( … greedfall the travelers graveWebMar 27, 2024 · Regardless of the oxygen, in senescent cells PKM2, SERPINE1, and VEGFA were upregulated while ANKRD37, DDIT4, HIF1A, and TXNIP were downregulated. Also, ADORA2B, BNIPL, CCNG2, EGLN1, MAP3K1, MXI1, and P4HA1 were downregulated under hypoxia. The effect of oxygen was more pronounced at earlier passages both on … flo shaughnessyWebMar 9, 2010 · REDD1 (also known as RTP801, DDIT4, and Dig1) was initially identified as a hypoxia-regulated HIF-1 target gene involved in regulation of cell survival ().Subsequent genetic studies demonstrated a major function of REDD1 and its orthologs as a hypoxia-induced regulator of TORC1 activity both in Drosophila and mammalian cells (14, … flo seattleWebMar 29, 2024 · A novel nonepigenetic function of HDAC4 induced by dexamethasone, through which it can directly modulate HIF-1a activity and promote the upregulation of … flosheen 32WebDec 29, 2016 · The mRNAs ITGB1, HIF1A, and DDIT4 were selected as core mRNAs, which are mainly involved in biological processes, such as matrix organization, cell cycle, … flos frisbi ceiling lightWebNov 23, 2016 · DDIT4 regulates mesenchymal stem cell fate by mediating between HIF1α and mTOR signalling. November 2016; Scientific Reports 6(1) ... NF-κB, p63, and HIF-1 [39]. ..... Low passage … flos heiress