Phorbiplatin
WebPhorbiplatin, a Highly Potent Pt(IV) Antitumor Prodrug That Can Be Controllably Activated by Red Light. Chem 2024-12 Journal article DOI: 10.1016/j.chempr.2024.08.021 Part of ISSN: 2451-9294 Show more detail. Source: Zhigang Wang A Cisplatin-Loaded Immunochemotherapeutic Nanohybrid Bearing Immune Checkpoint Inhibitors for … WebPhorbiplatin is scaffolded on the molecular structure of oxaliplatin. The controllable activation property and superior antitumor activity of phorbiplatin could significantly contribute to the development of photoactivatable anticancer prodrugs to reduce the adverse effects and conquer drug resistance of traditional platinum chemotherapy.
Phorbiplatin
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WebPhorbiplatin is a small-molecule platinum (IV) anti-cancer prodrug. Prodrug is a compound that will only be pharmacologically active after activation inside the body. Phorbiplatin is shown to be ... WebJan 7, 2024 · The new chemical compound, phorbiplatin, developed by Zhu Guangyu, Associate Professor in the university's Department of Chemistry and his team can increase the accuracy of chemotherapy. It offers hope for minimizing the damage that normal cells undergo during treatment for a broad range of cancers, in particular for breast and ovarian …
WebHair loss or alopecia in males is very common, and so is its treatment. Until now, platelet-rich plasma has been in use for hair regeneration, which has shown results but lacks … WebDec 12, 2024 · Phorbiplatin maintains its integrity without irradiation, but under irradiation with red light, the prodrug is quickly and efficiently activated, releasing oxaliplatin and PPA. The prodrug shows significant antitumor activity both in …
WebJan 2, 2024 · Platelet-rich fibrin (PRF) has been proposed as an autologous membrane with the advantages of host accumulation of platelets and leukocytes with entrapment of … WebJun 9, 2024 · Phorbiplatin is stable and shows little cytotoxicity in the dark, while upon irradiation with red light the complex exhibits promising anticancer activities both in vitro and in vivo. The photocytotoxicity of phorbiplatin was nearly 1786-fold higher than that of oxaliplatin upon irradiation . Such high photocytotoxicity of phorbiplatin was ...
WebUnder short-period irradiation with low intensity of red light, without the need of any external catalyst, phorbiplatin is reduced to oxaliplatin, a first-line clinical antineoplastic, as well as …
WebJan 23, 2024 · Summary: A novel drug, named 'FerriIridium,' can simultaneously help diagnose and treat gastric cancer. The initially weakly active precursor (prodrug), based on an iridium-containing compound, is... csc roomWebOct 10, 2024 · The controllable activation property csc roll formerWebOct 3, 2024 · Phorbiplatin is a small-molecule platinum (IV) anti-cancer prodrug. Prodrug is a compound that will only be pharmacologically active after activation inside the body. Phorbiplatin is shown to... dyson cinetic big ball animal dealsWebJul 28, 2024 · Phorbiplatin, a Highly Potent Pt(IV) Antitumor Prodrug That Can Be Controllably Activated by Red Light. 2024, Chem. Show abstract. Selective activation of prodrugs within a tumor is particularly attractive because of their low damage to normal tissue. Here, we report the design, photoactivation mechanism, and antitumor activity of a … csc room assignment 2023 professionalWebOct 11, 2024 · Phorbiplatin is a small-molecule platinum(IV) anti-cancer prodrug, shown to be inert in the dark but can be activated under low-power red-light irradiation. "Under short-period irradiation with low intensity of red light (650 nm, 7 mW/cm2) and without any external catalyst, phorbiplatin is reduced to oxaliplatin, a first-line clinical ... dyson cinetic big ball animal maintenanceWebUnder short-period irradiation with low intensity of red light, without the need of any external catalyst, phorbiplatin is reduced to oxaliplatin, a first-line clinical antineoplastic, as well as ... csc room assignment region 11WebNov 6, 2024 · Herein, the photoactivatable platinum drugs based on the classification of the mechanism of photoactivation will be summarized. The complexes will be divided into groups based on their mechanisms of action, including photoreduction, photo-uncaging, and photodissociation. dyson cinetic big ball animal manual